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Citation

Thesis Title
Gut endogenous protein flows and postprandial metabolic utilization of dietary amino acids in simple-stomached animals and humans

Read article at Massey Research Online:

Ms Deglaire鈥檚 research focused on the dietary modulation of key elements of dietary protein quality: gut endogenous protein losses, required for estimating true protein digestibility; and metabolic utilization of dietary amino acids. The influence of the delivery form (intact or hydrolysed) of the milk protein, casein, was studied. Casein was labelled with a stable isotope (15N) to trace its fate after ingestion in rats, pigs, and humans. Results showed that, compared to intact casein, hydrolysed casein did not enhance ileal endogenous protein losses, supporting its practical use for determining gut endogenous protein losses. Intact and hydrolysed casein elicited the same nutritional value despite different metabolic fates. This has implications for assessing the nutritional quality of formulas based on hydrolysed casein for allergic infants or patients with reduced digestive capacities. Additionally, our understanding of the regulation of amino acid metabolism has been advanced.

Supervisors
Distinguished Professor Paul Moughan
Dr Gordon Reynolds
Distinguished Professor Harjinder Singh
Professor D Tome