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Dr Harikrishnan Mohana Kurup staff profile picture

Contact details +6469517622

Dr Harikrishnan Mohana Kurup MS(Pharm.), PhD

Postdoctoral Fellow

School of Food Technology and Natural Sciences

Experienced Post Doctoral Researcher with a demonstrated history of working in the field of organic chemistry with expertise in Nucleic acid chemistry, oligonucleotide synthesis, purification, and characterization. NMR-based kinetic assay for inhibitors developed towards APOBEC3 Proteins, Total Synthesis, Asymmetric Synthesis, Synthesis of bioactive compounds for different types of cancers. Industrial experience includes working as an R&D executive at Sun Pharma Advanced Research Co. Ltd (SPARC), Vadodara, India, developing novel small molecule inhibitors targeting kinases. Master's degree was focused on Medicinal chemistry, total synthesis of bioactive natural products, and asymmetric synthesis from the National Institute of Pharmaceutical Education and Research (NIPER), SAS NAGAR, Mohali, India. 

Post Doctoral Researcher working on the development of oligonucleotide-based inhibitors of  APOBEC3 Proteins, Research interests also include synthesis of novel modified nucleosides as transition state analogs of cytosine deamination, post-synthetic oligonucleotide transformations, and click chemistry. 

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Professional

Contact details

  • Location: A4.08, Science Tower A
    Campus: Manawatu

Qualifications

  • Master of Science (Pharm.) - National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab, India (2016)
  • Doctor of Philosophy - 黑料网 (2022)

Fellowships and Memberships

  • Member, Maurice Wilkins Centre for Molecular Biodiscovery (Other) (2018)

Research Expertise

Research Interests

Nucleoside, Nucleotide, and Oligonucleotide Chemistry

Organic synthesis 

Thematics

Health and Well-being

Area of Expertise

Field of research codes
Chemical Science (030000): Organic Chemical Synthesis (030503): Organic Chemistry (030500)

Research Outputs

Journal

Kvach, MV., Harjes, S., Kurup, HM., Jameson, GB., Harjes, E., & Filichev, VV. (2024). Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A. Beilstein Journal of Organic Chemistry. 20, 1088-1098
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Harjes, S., Kurup, HM., Rieffer, AE., Bayarjargal, M., Filitcheva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications. 14(1)
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Kurup, H.
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7
Kurup, HM., Kvach, MV., Harjes, S., Jameson, GB., Harjes, E., & Filichev, VV. (2023). Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A. Organic and Biomolecular Chemistry. 21(24), 5117-5128
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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4
Harjes, S., Kurup, HM., Rieffer, AE., Bayarjargal, M., Filichetva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications. 14, Retrieved from https://www.nature.com/articles/s41467-023-42174-w
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Kurup, H.
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Harjes, S., Kurup, HM., Rieffer, AE., Bayaijargal, M., Filitcheva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.. Nature Communications. 14, Retrieved from https://www.nature.com/articles/s41467-023-42174-w
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Kurup, H.
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Kurup, HM., Kvach, MV., Harjes, S., Barzak, FM., Jameson, GB., Harjes, E., . . . Filichev, VV. (2022). Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A. Biochemistry. 61(22), 2568-2578
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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5
Barzak, FM., Ryan, TM., Mohammadzadeh, N., Harjes, S., Kvach, MV., Kurup, HM., . . . Jameson, GB. (2022). Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity. Viruses. 14(9)
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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2
Stanton, JAL., O'Brien, R., Hall, RJ., Chernyavtseva, A., Ha, HJ., Jelley, L., . . . Blaikie, R. (2022). Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains. Frontiers in Public Health. 9
[Journal article]Authored by: Filichev, V., Kurup, H.
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3
Barzak, FM., Ryan, TM., Kvach, MV., Kurup, HM., Aihara, H., Harris, RS., . . . Jameson, GB. (2021). Small-angle x-ray scattering models of apobec3b catalytic domain in a complex with a single-stranded dna inhibitor. Viruses. 13(2)
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Kvach, MV., Barzak, FM., Harjes, S., Schares, HAM., Kurup, HM., Jones, KF., . . . Filichev, VV. (2020). Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA. ChemBioChem. 21(7), 1028-1035
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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14
3
Barzak, FM., Harjes, S., Kvach, MV., Kurup, HM., Jameson, GB., Filichev, VV., . . . Harjes, E. (2019). Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2′-deoxyzebularine. Organic and Biomolecular Chemistry. 17(43), 9435-9441
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Gangar, M., Harikrishnan, M., Goyal, S., Mungalpara, MN., & Nair, VA. (2016). A highly efficient and enantioselective synthesis of EEHP and EMHP: intermediates of PPAR agonists. TETRAHEDRON LETTERS. 57(31), 3462-3467
[Journal article]Authored by: Kurup, H.
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Gangar, M., Ittuveetil, A., Goyal, S., Pal, A., Harikrishnan, M., & Nair, VA. (2016). Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4 '-oxyneolignans. RSC ADVANCES. 6(104), 102116-102126
[Journal article]Authored by: Kurup, H.
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IP

Kurup, H., Filichev, VV., Harjes, E., Harjes, S., Jameson, G., Kvach, M., . . . Su, Y.(2022). . WO2022162536: SINGLE STRANDED DNA ENZYME INHIBITORS
[Patent]Authored by: Filichev, V., Jameson, G., Kurup, H.Contributed to by: Kurup, H.
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Media and Links

Other Links

  • - Development of Powerful Inhibitors of APOBEC3 Enzymes